4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

Base Information

Chemical Name:4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside
CAS No.:283170-27-4
Molecular Formula:C₃₇H₄₉ClN₂O₁₀
Molecular Weight:717.256
Hs Code.:

4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

Synonyms:4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

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Chemical Property of 4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

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Technology Process of 4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

There total 2 articles about 4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80565-30-6
4'-chlorobiphenyl-4-carbaldehyde

: 283170-27-4
4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIPEA / dimethylformamide / 0.5 h / 55 °C

1.2: NaBH₃CN / dimethylformamide; tetrahydrofuran / 3 h / 55 °C

2.1: 58 mg / TBAF / dimethylformamide; tetrahydrofuran / 55 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00743-3

Reference yield:

: (3-{4-[(2S,3R,4S,5S,6R)-3-((2S,4S,5S,6S)-4-Amino-5-hydroxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy]-3,5-dimethoxy-phenyl}-propyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

: 283170-27-4
4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIPEA / dimethylformamide / 0.5 h / 55 °C

1.2: NaBH₃CN / dimethylformamide; tetrahydrofuran / 3 h / 55 °C

2.1: 58 mg / TBAF / dimethylformamide; tetrahydrofuran / 55 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00743-3

Reference yield: 23.0%

: 82198-76-3
vancomycin aglycon

: 283170-27-4
4-(3-aminopropyl)-2,6-dimethoxyphenyl 2-O-(3-[4-(4-chlorophenyl)benzylamino]-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranoside

: C₈₁H₈₈N₉O₂₄Cl₃C₈H₈O₂CH₂NH

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4020(02)00743-3