4-(2-CHLOROPHENYL)BENZALDEHYDE

Base Information

• Chemical Name: 4-(2-CHLOROPHENYL)BENZALDEHYDE
• CAS No.: 80565-30-6
• Molecular Formula: C13H9 Cl O
• Molecular Weight: 216.667
• Hs Code.: 2913000090
• Mol file: 80565-30-6.mol

Synonyms:4-(4-Chlorophenyl)benzaldehyde;4'-Chloro-1,1'-biphenyl-4-carboxaldehyde; 4'-Chlorobiphenyl-4-carboxaldehyde

Chemical Property of 4-(2-CHLOROPHENYL)BENZALDEHYDE

Chemical Property:

• Melting Point: 115-118oC
• Boiling Point: 354.3°Cat760mmHg
• Flash Point: 183.9°C
• PSA: 17.07000
• Density: 1.214g/cm³
• LogP: 3.81950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4''-Chlorobiphenyl-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4''-Chlorobiphenyl-4-carbaldehyde is used in the synthesis of thieno[3,2-d]pyrimidines as scaffold of antimicrobial activity.

Technology Process of 4-(2-CHLOROPHENYL)BENZALDEHYDE

There total 22 articles about 4-(2-CHLOROPHENYL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Chlorophenylboronic acid (1679-18-1) + 4-bromo-benzaldehyde (1122-91-4) → 4'-chlorobiphenyl-4-carbaldehyde (80565-30-6)

Guidance literature:

With potassium fluoride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1021/jo025732j

Reference yield: 95.0%

bromochlorobenzene (106-39-8) + 4-formylphenylboronic acid, (87199-17-5) → 4'-chlorobiphenyl-4-carbaldehyde (80565-30-6)

Guidance literature:

With potassium phosphate; sodium tetrachloropalladate(II); sodium dodecyl-sulfate; In water; at 100 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2008.12.063

Reference yield: 94.0%

4-Chlorophenylboronic acid (1679-18-1) + 4-chlorobenzaldehyde (104-88-1) → 4'-chlorobiphenyl-4-carbaldehyde (80565-30-6)

Guidance literature:

With C₂₇H₃₆Cl₃N₂Pd^(1-)*C₃H₉N*H⁽¹⁺⁾; sodium carbonate; In water; at 30 ℃; for 5h; Green chemistry;

DOI:10.1002/aoc.5955

upstream raw materials:

Dichloromethyl methyl ether

4'-biphenyl chloride

bromochlorobenzene

4-bromo-benzaldehyde

Downstream raw materials:

(4′-chloro-[1,1′-biphenyl]-4-yl)methanol

2-[4-(4-Chloro-phenyl)-phenyl]-1H-benzoimidazole-5-carboxylic Acid

4'-chlorobiphenyl-4-carboxylic acid

C₇₂H₇₂Cl₃N₉O₂₁