2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine

Base Information

• Chemical Name: 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine
• CAS No.: 1000550-74-2
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Hs Code.: 2932990090
• Mol file: 1000550-74-2.mol

Synonyms:2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine

Chemical Property of 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-[4-(Tetrahydropyran-2-yloxy)phenyl]ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine

There total 5 articles about 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-{2-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethyl}formamide (1521270-08-5) → 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine (1000550-74-2)

Guidance literature:

With hydrazine; In ethanol; at 78 ℃; for 12h; Temperature; Time;

DOI:10.2478/s11696-013-0449-y

Reference yield:

C21H25NO4 → 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine (1000550-74-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; Sealed tube;

DOI:10.1002/ejoc.202101059

Reference yield:

tyrosamine (51-67-2) → 2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-amine (1000550-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 10 h / 20 °C

2: pyridinium p-toluenesulfonate / dichloromethane / 9 h / 20 °C

3: hydrazine / ethanol / 12 h / 78 °C

With pyridinium p-toluenesulfonate; hydrazine; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.2478/s11696-013-0449-y

upstream raw materials:

N-[2-(4-hydroxyphenyl)ethyl]formamide

tyrosamine

N-{2-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethyl}formamide

N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine

Downstream raw materials:

cannabisin F