benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate

Base Information

• Chemical Name: benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate
• CAS No.: 29655-46-7
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.316
• Hs Code.: 2924299090
• European Community (EC) Number: 806-905-4
• DSSTox Substance ID: DTXSID10555935
• Nikkaji Number: J1.046.842F
• Wikidata: Q82437394
• Mol file: 29655-46-7.mol

Synonyms:29655-46-7;benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate;Benzyl 4-hydroxyphenethylcarbamate;Carbobenzyloxytyramine;N-carbobenzoxytyramine;N-CBZ-TYRAMINE;SCHEMBL6554125;Benzyl4-hydroxyphenethylcarbamate;DTXSID10555935;YMODWJQJBRHYIP-UHFFFAOYSA-N;AKOS025393558;SS-4678;Benzyl [2-(4-hydroxyphenyl)ethyl]carbamate;N-(benzyloxycarbonyl)-p-hydroxyphenethylamine;4-(2-(phenylmethyloxycarbonylamino)ethyl)phenol;D96158;EN300-7132091;Carbamic acid, N-[2-(4-hydroxyphenyl)ethyl]-, phenylmethyl ester

Chemical Property of benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate

Chemical Property:

• PSA: 62.05000
• LogP: 3.06550
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 271.12084340
• Heavy Atom Count: 20
• Complexity: 281

Purity/Quality:

99% ^*data from raw suppliers

Benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCC2=CC=C(C=C2)O

Technology Process of benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate

There total 8 articles about benzyl N-[2-(4-hydroxyphenyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tyrosamine (51-67-2) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine (29655-46-7)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 20 ℃; for 4h;

DOI:10.1055/s-0032-1317528

Reference yield: 96.0%

tyrosamine (51-67-2) + N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) → N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine (29655-46-7)

Guidance literature:

In tetrahydrofuran; 1 h, 0 deg C and 3 h, 25 deg C;

DOI:10.1016/S0040-4039(98)02696-3

Reference yield: 95.0%

benzyl (4-(benzyloxy)phenethyl)carbamate (1067665-51-3) → N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine (29655-46-7)

Guidance literature:

With pentamethylbenzene,; boron trichloride; In dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1055/S-2008-1077980

upstream raw materials:

tyrosamine

benzyl chloroformate

N-(Benzyloxycarbonyloxy)succinimide

Z-L-Tyr-OH

Downstream raw materials:

(4-dimethylcarbamoyloxy-phenethyl)-carbamic acid benzyl ester

{4-[2-methyl-1-(2-oxo-oxazolidin-4-yl)-propoxy]-phenethyl}-carbamic acid benzyl ester

4-<2-(benzyloxycarbonylamino)ethyl>phenyl 3-O-acetyl-2,4-di-O-methyl-α-L-rhamnopyranoside

{2-[4-(2-Methoxy-ethoxymethoxy)-phenyl]-ethyl}-carbamic acid benzyl ester