Technology Process of (3S,4R)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid (S)-2-methyl-1-pentafluorophenyloxycarbonyl-propyl ester
There total 14 articles about (3S,4R)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid (S)-2-methyl-1-pentafluorophenyloxycarbonyl-propyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / K2CO3 / Bu4NI / dimethylformamide / 1 h / 20 °C
2: 60 percent / EDAC*HCl; DMAP / CH2Cl2 / 0 - 20 °C
3: 100 percent / Pd(PPh3)4; morpholine / tetrahydrofuran / 20 °C
4: Pyr / CH2Cl2
With
morpholine; pyridine; dmap; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja010222c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / 1N aq. H2SO4; NaNO2 / 0 - 20 °C
2: 96 percent / K2CO3 / Bu4NI / dimethylformamide / 1 h / 20 °C
3: 60 percent / EDAC*HCl; DMAP / CH2Cl2 / 0 - 20 °C
4: 100 percent / Pd(PPh3)4; morpholine / tetrahydrofuran / 20 °C
5: Pyr / CH2Cl2
With
morpholine; pyridine; dmap; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja010222c
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / EDAC*HCl; DMAP / CH2Cl2 / 0 - 20 °C
2: 83 percent / tetrahydrofuran / -78 °C
3: 77 percent / potassium borohydride / methanol / -30 - 0 °C
4: 82 percent / 2,6-lutidine / CH2Cl2 / 20 °C
5: 81 percent / aq. NaOH / tetrahydrofuran; methanol / 0 - 20 °C
6: 60 percent / EDAC*HCl; DMAP / CH2Cl2 / 0 - 20 °C
7: 100 percent / Pd(PPh3)4; morpholine / tetrahydrofuran / 20 °C
8: Pyr / CH2Cl2
With
morpholine; pyridine; 2,6-dimethylpyridine; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); potassium borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja010222c
