6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine

Base Information

• Chemical Name: 6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine
• CAS No.: 130024-06-5
• Molecular Formula: C₁₁H₈Cl₂N₄
• Molecular Weight: 267.117
• Mol file: 130024-06-5.mol

Synonyms:6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine

Chemical Property of 6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine

There total 1 articles about 6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4,6-dichloro-1-p-chlorophenylpyrazolo<3,4-d>pyrimidine (5334-34-9) → 6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine (130024-06-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; chloroform; Ambient temperature;

DOI:10.1002/jhet.5570270401

Reference yield: 80.0%

6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine (130024-06-5) + ethyl bromoacetate (105-36-2) → Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate (130024-09-8)

Guidance literature:

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1002/jhet.5570270401

Reference yield:

6-Chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine (130024-06-5) → 1-p-Chlorophenyl-4,6,7,8-tetrahydro-1H-imidazo<1,2-a>pyrazolo<3,4-d>pyrimidin-7-one (130023-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 10N aq. NaOH, Bu₄NI / CH₂Cl₂ / 3 h / Ambient temperature

2: 10percent ethanolic NH₃ / 3 h / 120 °C

With sodium hydroxide; ammonia; tetra-(n-butyl)ammonium iodide; In dichloromethane;

DOI:10.1002/jhet.5570270401

upstream raw materials:

4,6-dichloro-1-p-chlorophenylpyrazolo<3,4-d>pyrimidine

Downstream raw materials:

Ethyl 6-chloro-1-p-chlorophenyl-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate

1-p-Chlorophenyl-4,6,7,8-tetrahydro-1H-imidazo<1,2-a>pyrazolo<3,4-d>pyrimidin-7-one