(2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

Base Information

Chemical Name:(2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate
CAS No.:854184-51-3
Molecular Formula:C₁₄H₂₆O₃
Molecular Weight:242.359
Hs Code.:

Synonyms:(2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

Chemical Property:

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Technology Process of (2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

There total 6 articles about (2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 2043-61-0
cyclohexanecarbaldehyde

: 854184-51-3
(2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

: 127422-17-7
(2S,3S)-tert-butyl 3-cyclohexyl-3-hydroxy-2-methylpropanoate

Guidance literature:: With diethoxymethylane; (S,S)-Rh(Phebox-bn)(OAc)2; In toluene; at 50 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1021/ja050698m

Reference yield:

: C₂₇H₄₇BO₂

: 2043-61-0
cyclohexanecarbaldehyde

: 854184-51-3
(2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

: 127422-17-7
(2S,3S)-tert-butyl 3-cyclohexyl-3-hydroxy-2-methylpropanoate

Guidance literature:: C₂₇H₄₇BO₂; cyclohexanecarbaldehyde; In diethyl ether; at -78 ℃; for 12h; Inert atmosphere;

With dihydrogen peroxide; In methanol; diethyl ether; at 20 ℃; for 6h; Overall yield = 70 %; Overall yield = 36 mg; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol401679g

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 2043-61-0
cyclohexanecarbaldehyde

: 854184-51-3
(2R,3R)-tert-butyl-3-cyclohexyl-3-hydroxy-2-methylpropanoate

: 127422-17-7
(2S,3S)-tert-butyl 3-cyclohexyl-3-hydroxy-2-methylpropanoate

: 127422-17-7,127422-18-8
(2R,3S)-3-Cyclohexyl-3-hydroxy-2-methyl-propionic acid tert-butyl ester

: 127422-18-8
(2S,3R)-3-Cyclohexyl-3-hydroxy-2-methyl-propionic acid tert-butyl ester

Guidance literature:: With [CuF(PPh₃)3]*2MeOH; C₄₄H₃₇FeN₃P₂; phenylsilane; In toluene; at -50 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1055/s-0029-1216724