(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

Base Information

Chemical Name:(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate
CAS No.:1392820-83-5
Molecular Formula:C₃₁H₄₈O₅Si₂
Molecular Weight:556.89
Hs Code.:

Synonyms:(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

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Chemical Property of (4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

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Technology Process of (4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

There total 7 articles about (4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₆O₄Si₂

: 108-24-7
acetic anhydride

: 1392820-83-5
(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo301122b

Reference yield:

: 1392820-82-4
(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-one

: 1392820-83-5
(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 4 h / -78 °C / Inert atmosphere

2: pyridine; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; dmap; diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1021/jo301122b

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1392820-83-5
(4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(2-((tertbutyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / 4 h / -78 °C / Inert atmosphere

3: pyridine; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; dmap; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo301122b