(1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Base Information

Chemical Name:(1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate
CAS No.:1609286-85-2
Molecular Formula:CF₃O₃S*C₂₁H₂₇N₂
Molecular Weight:456.529
Hs Code.:

Synonyms:(1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

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Chemical Property of (1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

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Technology Process of (1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

There total 6 articles about (1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 141804-57-1,646994-91-4
(1S,2S,4S,5S)-2,5-bis(phenylmethyl)-1,4-diazabicyclo[2.2.2]octane

: 333-27-7
methyl trifluoromethanesulfonate

: 1609286-85-2
(1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Guidance literature:: In diethyl ether; at 0 - 20 ℃; for 3h;

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1609286-85-2
(1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: formic acid / 2 h / 20 °C

2.2: 2 h / Reflux

3.1: borane-THF / tetrahydrofuran / 0 °C / Reflux

3.2: 12 h / 20 °C

4.1: triethylamine / toluene / 12 h / Reflux

5.1: diethyl ether / 3 h / 0 - 20 °C

With formic acid; borane-THF; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1609286-85-2
(1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: formic acid / 2 h / 20 °C

2.2: 2 h / Reflux

3.1: borane-THF / tetrahydrofuran / 0 °C / Reflux

3.2: 12 h / 20 °C

4.1: triethylamine / toluene / 12 h / Reflux

5.1: diethyl ether / 3 h / 0 - 20 °C

With formic acid; borane-THF; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;