4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

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Chemical Name:4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide
CAS No.:1381979-62-9
Molecular Formula:C₃₂H₃₂F₃N₅O₃S
Molecular Weight:623.699
Hs Code.:

Synonyms:4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

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Chemical Property of 4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

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Technology Process of 4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

There total 7 articles about 4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381977-95-2
4-((4-(4-(3,3-difluoro-4-phenylpyrrolidine-1-carbonyl)-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl)methyl)benzenesulfonamide

: 1381979-63-0
4-{[4-(4-{[(4S)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

: 1381979-62-9
4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

Guidance literature:: With ChiralPak₁A; In ethanol; hexane; chloroform; Resolution of racemate;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1381979-63-0
4-{[4-(4-{[(4S)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

: 1381979-62-9
4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2: 1,4-dioxane / 0.33 h / 120 °C

3: dichloromethane / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 90 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6: potassium carbonate / acetonitrile / 1 h / 50 °C

7: ChiralPak₁A / ethanol; hexane; chloroform / Resolution of racemate

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; hexane; dichloromethane; chloroform; acetonitrile; butan-1-ol;

Reference yield:

: 1381980-33-1
tert-butyl 4-(3-(3,3-difluoro-4-phenylpyrrolidin-1-yl)-3-oxopropanoyl)piperidine-1-carboxylate

: 1381979-63-0
4-{[4-(4-{[(4S)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

: 1381979-62-9
4-{[4-(4-{[(4R)-3,3-difluoro-4-phenylpyrrolidin-1-yl]carbonyl}-1-(4-fluorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl]methyl}benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 4 h / Reflux

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: potassium carbonate / acetonitrile / 1 h / 50 °C

5: ChiralPak₁A / ethanol; hexane; chloroform / Resolution of racemate

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; hexane; dichloromethane; chloroform; acetonitrile; butan-1-ol;