4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride

Base Information

• Chemical Name: 4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride
• CAS No.: 1383543-83-6
• Molecular Formula: C₁₄H₂₀N₂O₆*ClH
• Molecular Weight: 348.784
• Mol file: 1383543-83-6.mol

Synonyms:4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride

Chemical Property of 4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride

Chemical Property:

Purity/Quality:

100% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride

There total 1 articles about 4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 4-(2-methoxy-5-nitro-4-(1-trifluoroacetamido-ethyl)phenoxy)butanoate (162827-96-5) → 4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride (1383543-83-6)

Guidance literature:

With hydrogenchloride; In methanol; for 36h; Inert atmosphere; Reflux; Solvolysis;

DOI:10.1039/c2ob25440a

Reference yield:

4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride (1383543-83-6) + 2-[2-[2-(2-[[(tert-butoxy)carbonyl]amino]ethoxy)ethoxy]ethoxyl]acetic acid (462100-06-7) → 4-{4-[14-(tert-butoxycarbonyl)amino-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid methyl ester (1383543-84-7)

Guidance literature:

2-[2-[2-(2-[[(tert-butoxy)carbonyl]amino]ethoxy)ethoxy]ethoxyl]acetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -20 ℃; for 6h;

4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1039/c2ob25440a

Reference yield:

4-[2-methoxy-5-nitro-4-(1-aminoethyl)phenoxy]butanoic acid methyl ester hydrochloride (1383543-83-6) → C22H35N3O10

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 6 h / -20 °C

1.2: 14 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c2ob25440a

upstream raw materials:

methyl 4-(2-methoxy-5-nitro-4-(1-trifluoroacetamido-ethyl)phenoxy)butanoate

Downstream raw materials:

4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid methyl ester

4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

4-{4-[14-(tert-butoxycarbonyl)amino-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid methyl ester