4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Base Information

Chemical Name:4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester
CAS No.:1393183-02-2
Molecular Formula:C₄₄H₄₆N₄O₁₄
Molecular Weight:854.868
Hs Code.:

4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Synonyms:

Suppliers and Price of 4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

There total 9 articles about 4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: C₃₈H₄₃N₃O₁₂

: 1393183-02-2
4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at -20 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1039/c2ob25440a

Reference yield:

: 1383543-84-7
4-{4-[14-(tert-butoxycarbonyl)amino-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid methyl ester

: 1393183-02-2
4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

4: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 h / -20 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25440a

Reference yield:

: 1146195-73-4
methyl 2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-oate

: 1393183-02-2
4-{4-[14-(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxycarbonylamino)-4-oxo-6,9,12-trioxa-3-azatetradec-2-yl]-2-methoxy-5-nitrophenoxy}butanoic acid 4-nitophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 6 h / -20 °C

2.2: 14 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

6.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 20 h / -20 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25440a