N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide

Base Information

• Chemical Name: N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide
• CAS No.: 247090-56-8
• Molecular Formula: C₂₀H₁₇ClF₃N₃O₃S
• Molecular Weight: 471.887

Synonyms:N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide

Chemical Property of N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide

Chemical Property:

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Technology Process of N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide

There total 3 articles about N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

chloroacetyl chloride (79-04-9) + N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-[(3-aminophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide (247090-60-4) → N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide (247090-56-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h;

DOI:10.1021/jm990027x

Reference yield:

3-aminothiophenol (22948-02-3) → N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide (247090-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent

2: 94 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 4 h

With N-ethyl-N,N-diisopropylamine; In dichloromethane; 2: Acylation;

DOI:10.1021/jm990027x

Reference yield:

4-amino-2-trifluoromethylbenzonitrile (654-70-6) → N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-({3-[(2-chloroacetyl)amino]phenyl}sulfanyl)-2-hydroxy-2-methylpropanamide (247090-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent

2: 94 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 4 h

With N-ethyl-N,N-diisopropylamine; In dichloromethane; 2: Acylation;

DOI:10.1021/jm990027x

upstream raw materials:

chloroacetyl chloride

N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-[(3-aminophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

3-aminothiophenol

4-amino-2-trifluoromethylbenzonitrile

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