benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

Base Information

• Chemical Name: benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate
• CAS No.: 260784-04-1
• Molecular Formula: C₁₈H₂₄N₂O₄
• Molecular Weight: 332.4
• Mol file: 260784-04-1.mol

Synonyms:benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

Chemical Property of benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

There total 1 articles about benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-Ac-Leu (1188-21-2) + benzyl (R)-aziridine-2-carboxylate (86123-05-9) → benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate (260784-04-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 6h;

DOI:10.1016/S0040-4020(99)00989-8

Reference yield: 94.0%

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate (260784-04-1) → 2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-acrylic acid benzyl ester

Guidance literature:

With water; magnesium bromide; In tetrahydrofuran; at 0 ℃; for 4h;

DOI:10.1016/S0040-4020(99)00989-8

Reference yield: 80.0%

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate (260784-04-1) → benzyl (2R,2'S)-2-(2'-acetamido-4'-methylpentanoyl)amino-3-hydroxypropionate

Guidance literature:

With water; magnesium bromide; In tetrahydrofuran; at 0 ℃; for 4h;

DOI:10.1016/S0040-4020(99)00989-8

upstream raw materials:

N-Ac-Leu

benzyl (R)-aziridine-2-carboxylate