Hydrazinecarboxylic acid, 2-(3-furanylmethyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Hydrazinecarboxylic acid, 2-(3-furanylmethyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 150767-03-6
• Molecular Formula: C₁₀H₁₆N₂O₃
• Molecular Weight: 212.249
• Mol file: 150767-03-6.mol

Synonyms:Hydrazinecarboxylic acid, 2-(3-furanylmethyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Hydrazinecarboxylic acid, 2-(3-furanylmethyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 63.50000
• LogP: 2.59070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydrazinecarboxylic acid, 2-(3-furanylmethyl)-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Hydrazinecarboxylic acid, 2-(3-furanylmethyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-(1-aza-2-(3-furyl)vinyl)(tert-butoxy)-carboxamide (150767-01-4) → N1-<(tert-butyloxy)carbonyl>-N2-(3-furanylmethyl)hydrazine (150767-03-6)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 65 ℃; for 4h; pH=3;

DOI:10.1021/jm060212s

Reference yield:

furan-3-carboxaldehyde (498-60-2) → N1-<(tert-butyloxy)carbonyl>-N2-(3-furanylmethyl)hydrazine (150767-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / conc. HCl / tetrahydrofuran

2: 46 percent / NaCNBH₃; acetic acid / methanol / 4 h / 65 °C / pH 3

With hydrogenchloride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1021/jm060212s

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → N1-<(tert-butyloxy)carbonyl>-N2-(3-furanylmethyl)hydrazine (150767-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / conc. HCl / tetrahydrofuran

2: 46 percent / NaCNBH₃; acetic acid / methanol / 4 h / 65 °C / pH 3

With hydrogenchloride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1021/jm060212s

upstream raw materials:

N-(1-aza-2-(3-furyl)vinyl)(tert-butoxy)-carboxamide

furan-3-carboxaldehyde

t-butoxycarbonylhydrazine

Refernces

• 1、 Sham, Hing L.,Betebenner, David A.,Zhao, Chen,Wideburg, Norman E.,Saldivar, Ayda,et al.. "Facile Synthesis of Potent HIV-1 Protease Inhibitors containing a Novel Pseudo-symmetric Dipeptide Isostere". . p. 1052 - 1053. Retrieved 2007/10/02.