1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Base Information

Chemical Name:1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea
CAS No.:1355346-42-7
Molecular Formula:C₃₂H₃₃N₅O₄
Molecular Weight:551.645
Hs Code.:

Synonyms:1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

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Chemical Property of 1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

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Technology Process of 1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

There total 6 articles about 1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1355347-36-2
2-tert-butyl-1-methyl-4-phenyl-1H-imidazole-5-carboxylic acid

: 347161-75-5
3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

: 1355346-42-7
1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Guidance literature:: 2-tert-butyl-1-methyl-4-phenyl-1H-imidazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In chloroform; for 1h; Reflux;

3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline; In chloroform; Reflux;

Reference yield:

: 3885-45-8
ethyl 2,3-dioxo-3-phenylpropanoate

: 1355346-42-7
1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 50 °C

4.1: triethylamine; diphenyl phosphoryl azide / chloroform / 1 h / Reflux

4.2: Reflux

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; ammonium acetate; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 2-chloro p-aminophenol hydrochloride

: 1355346-42-7
1-(2-tert-butyl-1-methyl-4-phenyl-1H-imidazol-5-yl)-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 100 °C

2.1: triethylamine; diphenyl phosphoryl azide / chloroform / 1 h / Reflux

2.2: Reflux

With diphenyl phosphoryl azide; sodium hydride; triethylamine; In chloroform; dimethyl sulfoxide;