3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

Base Information

Chemical Name:3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline
CAS No.:347161-75-5
Molecular Formula:C17H15ClN2O3
Molecular Weight:330.771
Hs Code.:
ChEMBL ID:CHEMBL3667503
DSSTox Substance ID:DTXSID401231422
Mol file:347161-75-5.mol

Synonyms:3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline;347161-75-5;SCHEMBL168497;CHEMBL3667503;DCFZOECVVBSZLL-UHFFFAOYSA-N;BDBM153648;DTXSID401231422;3-Chloro-4-(6,7-dimethoxyquinolin-4-yloxy)aniline;3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]-aniline;US8999982, 3-chloro-4-((6,7- dimethoxyquinolin-4- yl)oxy)aniline

Suppliers and Price of 3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

Chemical Property:

PSA：66.60000
LogP:4.86110
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:330.0771200
Heavy Atom Count:23
Complexity:387

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)N)Cl

Technology Process of 3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

There total 5 articles about 3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 35654-56-9
6,7-dimethoxy-4-chloroquinoline

: 3964-52-1
2-chloro 4-aminophenol

: 347161-75-5
3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

Guidance literature:: 2-chloro 4-aminophenol; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

6,7-dimethoxy-4-chloroquinoline; In dimethyl sulfoxide; at 110 ℃; for 12h;
DOI:10.1021/jm030427r

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 347161-75-5
3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaOMe / 1,2-dimethoxy-ethane / 1.17 h / 20 °C

1.2: 95 percent / 1,2-dimethoxy-ethane / 2 h / 20 °C

2.1: POCl₃ / Heating

3.1: NaH / dimethylsulfoxide / 0.17 h / 20 °C

3.2: 62 percent / dimethylsulfoxide / 12 h / 110 °C

With sodium methylate; sodium hydride; trichlorophosphate; In 1,2-dimethoxyethane; dimethyl sulfoxide;
DOI:10.1021/jm030427r

Reference yield:

: 127285-54-5,13425-93-9
1,4-dihydro-6,7-dimethoxy-4-oxoquinoline

: 347161-75-5
3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: POCl₃ / Heating

2.1: NaH / dimethylsulfoxide / 0.17 h / 20 °C

2.2: 62 percent / dimethylsulfoxide / 12 h / 110 °C

With sodium hydride; trichlorophosphate; In dimethyl sulfoxide;
DOI:10.1021/jm030427r