METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE

Base Information

• Chemical Name: METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE
• CAS No.: 474645-93-7
• Molecular Formula: C14H17F3N2O2
• Molecular Weight: 302.29
• Mol file: 474645-93-7.mol

Synonyms:METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE

Chemical Property of METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE

Chemical Property:

• PSA: 53.85000
• LogP: 4.03910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE

There total 13 articles about METHYL [2-ETHYL-6-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINOLIN-4-YL]CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3R)-[3-(4-trifluoromethylphenylamino)pentanoyl]carbamic acid methyl ester (474645-92-6) → (2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid methyl ester (474645-93-7)

Guidance literature:

With sodium tetrahydroborate; magnesium chloride; In ethanol; water; at -10 - 0 ℃;

DOI:10.1021/jo071031g

Reference yield: 91.0%

(1-benzotriazol-1-yl-propyl)-(4-trifluoromethyl-phenyl)-amine (343798-02-7) + methyl ethenylcarbamate (15204-93-0) → (2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid methyl ester (474645-93-7)

Guidance literature:

(1-benzotriazol-1-yl-propyl)-(4-trifluoromethyl-phenyl)-amine; methyl ethenylcarbamate; C₄₀H₂₄BO₄^(1-)*H⁽¹⁺⁾; In cyclopentyl methyl ether; toluene; at -15 ℃; for 2h;

With sodium methylate; In methanol; cyclopentyl methyl ether; toluene; at -15 - 20 ℃; for 3.25h;

Reference yield: 85.5%

methyl (3R)-[l-(benzotriazol-1-yl)-3-(4-trifluoromethylphenyl)-aminopentyl]-carbamate → (2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid methyl ester (474645-93-7)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 50 ℃; for 1h;

upstream raw materials:

(3R)-[3-(4-trifluoromethylphenylamino)pentanoyl]carbamic acid methyl ester

(E)-pent-2-enoyl-carbamic acid methyl ester

4-trifluoromethylphenylamine

1,2,3-Benzotriazole

Downstream raw materials:

torcetrapib