474645-92-6

Upstream product

• 948847-52-7 (E)-pent-2-enoyl-carbamic acid methyl ester 
• 455-14-1 4-trifluoromethylphenylamine 
• 667937-05-5 (3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide 
• 79-22-1 methyl chloroformate 
• 400090-60-0 (R)-3-aminopentanenitrile 
• 1027896-34-9 (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone 
• 598-55-0 methyl carbamate 
• 1220112-72-0 methyl 2-pentenoylcarbamate 

Downstream Products

• 474645-93-7 (2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid methyl ester 
• 262352-17-0 torcetrapib 

Relevant academic research and scientific papers

SYNTHESIS OF IMIDE COMPOUNDS

The invention relates to a process for the production of an imide (1) (2) (3) via the enantioselective addition of an amine (2) to an alkene (3) wherein Y is OR, wherein R is alkyl or Bn, said process comprising: incubating Pd(OTf)2 with a phos

A concise asymmetric synthesis of torcetrapib

(Chemical Equation Presented) Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.

Asymmetric synthesis of the cholesteryl ester transfer protein inhibitor torcetrapib

Previously our group reported synthetic efforts used to synthesize kilogram quantities of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, 1, via a mid-stage resolution. This account describes research conducted to develop an asymmetri

PROCESS FOR PRODUCING OPTICALLY ACTIIVE BETA-AMINO ACID DERIVATIVES

The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a metho

METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE

The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a β-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active β-amino acid derivative of formula (5); 3) a step of amidating the optically active β-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).

Method for producing (R) -3- [4- (trifluoromethyl) phenylamino] -pentanoic acid amide derivative

The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protei