Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate

Base Information

• Chemical Name: Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate
• CAS No.: 138782-48-6
• Molecular Formula: C₂₇H₃₆O₈SSi
• Molecular Weight: 548.73
• Mol file: 138782-48-6.mol

Synonyms:Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate

Chemical Property of Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate

There total 4 articles about Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl benzenesulfonylacetate (34097-60-4) → Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate (138782-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / diethylammonium chloride, KF / toluene / 15 h / Heating

2: 80 percent / NaH / tetrahydrofuran / 1.) 0.5 h, 2.) 0.5 h

With potassium fluoride; diethyl amine hydrochloride; sodium hydride; In tetrahydrofuran; toluene;

Reference yield:

piperonal (120-57-0,30024-74-9) → Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate (138782-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / diethylammonium chloride, KF / toluene / 15 h / Heating

2: 80 percent / NaH / tetrahydrofuran / 1.) 0.5 h, 2.) 0.5 h

With potassium fluoride; diethyl amine hydrochloride; sodium hydride; In tetrahydrofuran; toluene;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → Methyl (Z)-3-(2H-1,3-benzodioxol-5-yl)-3-(4-tert-butyldimethylsilyloxybut-2-en-1-yloxy)-2-phenylsulfonylpropanoate (138782-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Et₃N, 4-DMAP / CH₂Cl₂ / 16 h

2: 80 percent / NaH / tetrahydrofuran / 1.) 0.5 h, 2.) 0.5 h

With dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(Z)-4-(tert-butyldimethylsilyloxy)but-2-en-1-ol

(E)-2-Benzenesulfonyl-3-benzo[1,3]dioxol-5-yl-acrylic acid methyl ester

piperonal

methyl benzenesulfonylacetate