Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester
• CAS No.: 108833-15-4
• Molecular Formula: C₃₈H₃₃N₅O₆S
• Molecular Weight: 687.776
• Mol file: 108833-15-4.mol

Synonyms:Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Chemical Property of Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

There total 15 articles about Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + 1H-Indole-2-carboxylic acid [2-((S)-5-benzyloxy-1-hydroxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide (108859-64-9) → Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester (108833-15-4)

Guidance literature:

With dmap; In pyridine; at 25 ℃; for 0.5h; Yield given;

DOI:10.1016/S0040-4039(00)84921-7

Reference yield:

((S)-5-Benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol (108833-14-3) → Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester (108833-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl dimethylaminopropylcarbodiimide / dimethylformamide / 48 h / 25 °C

2: DMAP / pyridine; various solvent(s) / 0.5 h / 25 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In pyridine; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)84921-7

Reference yield:

5-[((1H-indol-2-yl)carbonyl)amino]-1H-indole-2-carboxylic acid (101134-91-2) → Methanesulfonic acid (S)-5-benzyloxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester (108833-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl dimethylaminopropylcarbodiimide / dimethylformamide / 48 h / 25 °C

2: DMAP / pyridine; various solvent(s) / 0.5 h / 25 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In pyridine; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)84921-7

upstream raw materials:

methanesulfonyl chloride

1H-Indole-2-carboxylic acid [2-((S)-5-benzyloxy-1-hydroxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide

((S)-5-Benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol

5-[((1H-indol-2-yl)carbonyl)amino]-1H-indole-2-carboxylic acid

Downstream raw materials:

1H-Indole-2-carboxylic acid [2-((S)-5-benzyloxy-1-chloromethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide

U-71,184

Methanesulfonic acid (S)-5-hydroxy-3-{5-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester