(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide
CAS No.:1376191-48-8
Molecular Formula:C₄₂H₅₂ClN₇O₅
Molecular Weight:770.372
Hs Code.:

(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

Synonyms:(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

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Chemical Property of (S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

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Technology Process of (S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

There total 8 articles about (S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376191-43-3
(S)-ethyl 4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

: 1376191-48-8
(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / tetrahydrofuran; methanol; water / Reflux; Inert atmosphere

1.2: Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere

2.2: Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm300178u

Reference yield:

: C₁₅H₉ClIN

: 1376191-48-8
(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

3.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

4.1: potassium hydroxide / tetrahydrofuran; methanol; water / Reflux; Inert atmosphere

4.2: Inert atmosphere

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere

5.2: Inert atmosphere

With copper(l) iodide; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 1376191-48-8
(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-{4-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / methanol / Reflux; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

4.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

5.1: potassium hydroxide / tetrahydrofuran; methanol; water / Reflux; Inert atmosphere

5.2: Inert atmosphere

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere

6.2: Inert atmosphere

With copper(l) iodide; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u