(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

Base Information

Chemical Name:(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate
CAS No.:1428260-94-9
Molecular Formula:C₁₅H₁₇NO₅
Molecular Weight:291.304
Hs Code.:

Synonyms:(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

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Chemical Property of (S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

Chemical Property:

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Technology Process of (S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

There total 4 articles about (S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7486-35-3
tri-n-butyl(vinyl)tin

: 153413-52-6
(S)-2-benzyloxycarbonylamino-3-chlorocarbonyl-propionic acid methyl ester

: 1428260-94-9
(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

Guidance literature:: With trans benzyl(chloro)bis(triphenylphosphine)palladium(II); In toluene; for 3h; Reflux;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 1428260-94-9
(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2: methanol / 5.5 h / -10 - 20 °C

3: oxalyl dichloride / toluene

4: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); toluene-4-sulfonic acid; In methanol; toluene;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 1428260-94-9
(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 5.5 h / -10 - 20 °C

2: oxalyl dichloride / toluene

3: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); In methanol; toluene;
DOI:10.1016/j.tetlet.2013.01.130