(S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Base Information

Chemical Name:(S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate
CAS No.:1428260-95-0
Molecular Formula:C₂₂H₂₉NO₉
Molecular Weight:451.474
Hs Code.:

Synonyms:(S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Suppliers and Price of (S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

There total 5 articles about (S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1428260-94-9
(S)-diethyl (N-(benzyloxycarbonyl)-2-(3-oxo-4-(5-oxooxazolidin-4-yl))butyl)malonate

: 105-53-3
diethyl malonate

: 1428260-95-0
(S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Guidance literature:: With potassium carbonate; In dichloromethane; for 4h; Reflux;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 1428260-95-0
(S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2: methanol / 5.5 h / -10 - 20 °C

3: oxalyl dichloride / toluene

4: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

5: potassium carbonate / dichloromethane / 4 h / Reflux

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); potassium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2013.01.130

Reference yield:

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 1428260-95-0
(S)-1,1-diethyl 6-methyl 6-(benzyloxycarbonylamino)-4-oxohexane-1,1,6-tricarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 5.5 h / -10 - 20 °C

2: oxalyl dichloride / toluene

3: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 3 h / Reflux

4: potassium carbonate / dichloromethane / 4 h / Reflux

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); potassium carbonate; In methanol; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2013.01.130