N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

Base Information

Chemical Name:N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide
CAS No.:1428901-04-5
Molecular Formula:C₃₃H₄₀FN₃O₇S
Molecular Weight:641.761
Hs Code.:

Synonyms:N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

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Chemical Property of N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

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Technology Process of N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

There total 8 articles about N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3144-09-0
methanesulfonamide

: 1428899-72-2
2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

: 1428901-04-5
N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 70 ℃; for 2h; Microwave irradiation;

Reference yield:

: 109492-91-3
methyl 2-[4-(benzyloxy)phenyl]-2-methylpropanoate

: 1428901-04-5
N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: palladium on carbon; hydrogen / methanol; ethyl acetate / 4 h / 20 °C / Inert atmosphere

2.1: potassium phosphate / N,N-dimethyl acetamide / 6.5 h / 70 °C / Inert atmosphere

3.1: potassium phosphate / N,N-dimethyl acetamide / 10 h / 100 °C / Inert atmosphere

4.1: hydrogen; 5%-palladium/activated carbon / methanol; ethyl acetate / 3 h / 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / ethyl acetate / 1.25 h / 0 - 20 °C / Inert atmosphere

6.1: N,N-dimethyl acetamide / 2 h / 90 °C / Inert atmosphere

6.2: 2 h

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 45 - 55 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2 h / 70 °C / Microwave irradiation

With dmap; potassium phosphate; 5%-palladium/activated carbon; palladium on carbon; water; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; ethyl acetate;

Reference yield:

: 123342-40-5
methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

: 1428901-04-5
N-[3-(4-fluorophenoxy)-5-(4-{2-methyl-1-[(methylsulphonyl)amino]-1-oxo-2-propanyl}phenoxy)phenyl]-4-hydroxy-4-isobutyl-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate / N,N-dimethyl acetamide / 6.5 h / 70 °C / Inert atmosphere

2.1: potassium phosphate / N,N-dimethyl acetamide / 10 h / 100 °C / Inert atmosphere

3.1: hydrogen; 5%-palladium/activated carbon / methanol; ethyl acetate / 3 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / ethyl acetate / 1.25 h / 0 - 20 °C / Inert atmosphere

5.1: N,N-dimethyl acetamide / 2 h / 90 °C / Inert atmosphere

5.2: 2 h

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 45 - 55 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2 h / 70 °C / Microwave irradiation

With dmap; potassium phosphate; 5%-palladium/activated carbon; water; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; ethyl acetate;