2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Base Information

Chemical Name:2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid
CAS No.:1428899-72-2
Molecular Formula:C₃₂H₃₇FN₂O₆
Molecular Weight:564.654
Hs Code.:

Synonyms:2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

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Chemical Property of 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

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Technology Process of 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

There total 7 articles about 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428901-10-3
methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

: 1428899-72-2
2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 45 - 55 ℃;

Reference yield:

: 1428901-08-9
methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

: 1428899-72-2
2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / ethyl acetate / 1.25 h / 0 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 2 h / 90 °C / Inert atmosphere

2.2: 2 h

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 45 - 55 °C

With water; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate;

Reference yield:

: 123342-40-5
methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

: 1428899-72-2
2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / N,N-dimethyl acetamide / 6.5 h / 70 °C / Inert atmosphere

2.1: potassium phosphate / N,N-dimethyl acetamide / 10 h / 100 °C / Inert atmosphere

3.1: hydrogen; 5%-palladium/activated carbon / methanol; ethyl acetate / 3 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / ethyl acetate / 1.25 h / 0 - 20 °C / Inert atmosphere

5.1: N,N-dimethyl acetamide / 2 h / 90 °C / Inert atmosphere

5.2: 2 h

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 45 - 55 °C

With potassium phosphate; 5%-palladium/activated carbon; water; hydrogen; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate;