1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

Base Information

Chemical Name:1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine
CAS No.:710349-65-8
Molecular Formula:C₂₃H₂₈N₄O
Molecular Weight:376.502
Hs Code.:

Synonyms:1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

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Chemical Property of 1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

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Technology Process of 1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

There total 4 articles about 1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1-allyl-5-methylsulfanyl-2,3-dihydro-1H-1,4-benzodiazepine

: 710349-65-8
1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

Guidance literature:: With acetic acid; at 120 ℃; for 12h;
DOI:10.1016/j.bmc.2004.03.023

Reference yield:

: 5118-94-5
1,4-benzodiazepine-2,5-dione

: 710349-65-8
1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 37 percent / LiAlH₄ / tetrahydrofuran / 14 h / Heating

2: 53 percent / triethylamine / benzene / 2 h / Heating

3: 84 percent / P₂S₅; pyridine / 2.5 h / Heating

4: 65 percent / sodium ethoxide / ethanol / 2 h / Heating

5: 37 percent / acetic acid / 12 h / 120 °C

With pyridine; lithium aluminium tetrahydride; tetraphosphorus decasulfide; sodium ethanolate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; benzene;
DOI:10.1016/j.bmc.2004.03.023

Reference yield:

: 28544-83-4
1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one

: 710349-65-8
1-allyl-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2,3-dihydro-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / triethylamine / benzene / 2 h / Heating

2: 84 percent / P₂S₅; pyridine / 2.5 h / Heating

3: 65 percent / sodium ethoxide / ethanol / 2 h / Heating

4: 37 percent / acetic acid / 12 h / 120 °C

With pyridine; tetraphosphorus decasulfide; sodium ethanolate; acetic acid; triethylamine; In ethanol; benzene;
DOI:10.1016/j.bmc.2004.03.023