N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Base Information

Chemical Name:N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin
CAS No.:1287708-83-1
Molecular Formula:C₃₄H₄₁NO₉
Molecular Weight:607.701
Hs Code.:

Synonyms:N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Chemical Property:

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Technology Process of N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

There total 6 articles about N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1287709-17-4
(10R)-N-chloroacetyl-aminodihydroartemisinin

: 151135-94-3
C₁₇H₁₆O₄

: 1287708-83-1
N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;
DOI:10.1002/ardp.201000391

Reference yield:

: 1287709-16-3
10α-aminodihydroartemisinin

: 1287708-83-1
N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.201000391

Reference yield:

: 1119668-68-6
10-α-azidodihydroartemisinin

: 1287708-83-1
N-{4-[3-(2,5-dimethoxyphenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 2 h / 60 °C

1.2: 6 h

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Staudinger reaction / 1.2: Staudinger reaction;
DOI:10.1002/ardp.201000391