Piperazine, 1-(2-fluoroethyl)- (9CI)

Base Information

• Chemical Name: Piperazine, 1-(2-fluoroethyl)- (9CI)
• CAS No.: 541505-04-8
• Molecular Formula: C6H13FN2
• Molecular Weight: 132.181
• Hs Code.: 2933599090
• Mol file: 541505-04-8.mol

Synonyms:Piperazine, 1-(2-fluoroethyl)- (9CI)

Chemical Property of Piperazine, 1-(2-fluoroethyl)- (9CI)

Chemical Property:

• PSA: 15.27000
• LogP: 0.12780
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Fluoroethyl)piperazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-Fluoroethyl)piperazine is used as a PET radioligand for in vivo visualization of phosphodiesterase 5 (PDE5).

Technology Process of Piperazine, 1-(2-fluoroethyl)- (9CI)

There total 2 articles about Piperazine, 1-(2-fluoroethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluoroethyl bromide (762-49-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → N-(2-fluoroethyl)-piperazine (541505-04-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 23h; Heating / reflux;

Reference yield: 70.0%

tert-butyl 4-(2-fluoroethyl)piperazine-1-carboxylate (184042-58-8) → N-(2-fluoroethyl)-piperazine (541505-04-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.6b01666

Reference yield: 65.9%

N-(2-fluoroethyl)-piperazine (541505-04-8) + C20H17F3N2O3 → (S)-N-(1-(4-(2-fluoroethyl) piperazin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-(4-(trifluoromethyl)phenyl)acetamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1007/s00044-021-02793-8

upstream raw materials:

2-fluoroethyl bromide

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(2-fluoroethyl)piperazine-1-carboxylate

Downstream raw materials:

C₂₈H₃₆ClFN₈O₃S

8-(2-chlorophenyl)-6-[4-(2-fluoroethyl)piperazin-1-yl]-9-(2-methoxyethyl)-2-methylpurine

SKI₆₉₆

[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-1-{2-[4-(2-fluoroethyl)piperazin-1-yl]-2-oxoethyl}-5-methyl-1H-indole-3-carboxamide hydrochloride

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