2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester

Base Information

• Chemical Name: 2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester
• CAS No.: 80772-66-3
• Molecular Formula: C₁₉H₂₅NO₃
• Molecular Weight: 315.412
• Mol file: 80772-66-3.mol

Synonyms:2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester

Chemical Property of 2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester

There total 1 articles about 2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-2-(chloromethyl)cyclohexanecarbonitrile (10479-49-9) + 2-(4-hydroxyphenyl)propionic acid ethylester (56355-15-8) → 2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester (80772-66-3)

Guidance literature:

With sodium; Multistep reaction; 1.) ethanol, 2.) reflux, 48 h;

DOI:10.1021/jm00164a006

Reference yield:

2-[4-(2-Cyano-cyclohexylmethoxy)-phenyl]-propionic acid ethyl ester (80772-66-3) → 2-[4-(1-Carboxy-ethyl)-phenoxymethyl]-cyclohexanecarboxylic acid

Guidance literature:

With potassium hydroxide; In diethylene glycol; at 250 ℃; for 5h;

DOI:10.1021/jm00164a006

upstream raw materials:

trans-2-(chloromethyl)cyclohexanecarbonitrile

2-(4-hydroxyphenyl)propionic acid ethylester