7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Base Information

Chemical Name:7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one
CAS No.:76054-02-9
Molecular Formula:C₁₄H₁₀ClN₃O₃S
Molecular Weight:335.771
Hs Code.:

Synonyms:7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Chemical Property of 7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Technology Process of 7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

There total 9 articles about 7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 76053-99-1
6-Methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

: 76054-02-9
7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With sulfuryl dichloride; In acetic acid;
DOI:10.1002/ardp.19803130708

Reference yield: 28.0%

: 2-Amino-N-[5-chloro-4-methyl-3-(2-nitro-benzoyl)-thiophen-2-yl]-acetamide

: 76054-02-9
7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With isobutyric Acid; for 0.0833333h; Heating;
DOI:10.1002/ardp.19803130708

Reference yield:

: 40017-83-2
3-(2-Nitrophenyl)-3-oxopropionsaeurenitril

: 76054-02-9
7-Chloro-6-methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 46 percent / Et₃N / dioxane / 0.5 h / Heating

2: 96 percent

3: NaI

4: 80 percent / conc. aq. NH₃

5: 62 percent / isobutyric acid / 0.08 h / Heating

6: 55 percent / SO₂Cl₂ / acetic acid

With ammonium hydroxide; sulfuryl dichloride; triethylamine; isobutyric Acid; sodium iodide; In 1,4-dioxane; acetic acid;
DOI:10.1002/ardp.19803130708