40017-83-2

Usage

Uses

Used in Pharmaceutical Industry:
AKOS 93602 is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance their efficacy.
Used in Perfume and Cosmetics Industry:
AKOS 93602 is used as a fragrance ingredient in perfumes and cosmetics, leveraging its sweet, floral, and fruity scent to create appealing and long-lasting fragrances.
Used in Food Industry:
AKOS 93602 is used as a flavoring agent in the food industry, adding unique and desirable flavors to various food products, enhancing their taste and consumer appeal.
Used in Organic Synthesis and Research:
AKOS 93602 is utilized in organic synthesis and research for its potential to contribute to the development of new chemical compounds and advancements in scientific understanding.

InChI:InChI=1/C9H6N2O3/c10-6-5-9(12)7-3-1-2-4-8(7)11(13)14/h1-4H,5H2

Upstream product

• 91974-26-4 2-cyano-3-(2-nitro-phenyl)-3-oxo-propionic acid ethyl ester 
• 141342-35-0 (Z)-2-Cyano-3-hydroxy-3-(2-nitrophenyl)acrylsaeureethylester 
• 606-27-9 methyl 2-nitrobenzoate 
• 75-05-8 acetonitrile 
• 610-14-0 2-nitrobenzyl chloride 
• 151-50-8 potassium cyanide 
• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 

Downstream Products

• 855938-19-1 3-(2-hydroxyamino-phenyl)-3-oxo-propionitrile 
• 76053-67-3 E-4-Mercapto-2-(o-nitrobenzoyl)-crotonsaeurenitril 
• 40017-84-3 2-Amino-3-(o-nitrobenzoyl)-thiophen 
• 67718-54-1 2-Amino-4-methyl-3-(o-nitrobenzoyl)-thiophen 
• 76053-71-9 2-Amino-4-ethyl-3-(o-nitrobenzoyl)-thiophen 
• 102908-42-9 3-(2-aminophenyl)-3-oxopropanenitrile 
• 76053-69-5 (2-amino-5-methylthiophen-3-yl)(2-nitrophenyl)methanone 
• 76053-70-8 2-Amino-5-ethyl-3-(o-nitrobenzoyl)-thiophen 
• 76053-72-0 2-Amino-4,5-dimethyl-3-(o-nitrobenzoyl)-thiophen 
• 40017-86-5 2-Amino-N-[3-(2-nitro-benzoyl)-thiophen-2-yl]-acetamide 
• 76053-74-2 5-Acetyl-2-amino-3-(o-nitrobenzoyl)-thiophen 
• 76053-97-9 7-Methyl-5-(2-nitro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 76053-81-1 2-Iodo-N-[3-(2-nitro-benzoyl)-thiophen-2-yl]-acetamide 
• 40017-85-4 2-Chloro-N-[3-(2-nitro-benzoyl)-thiophen-2-yl]-acetamide 

Relevant academic research and scientific papers

One-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene

Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-butyl peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

AROMATIC DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF

The present invention relates to an aromatic derivative, a preparation method thereof and medical applications thereof. Particularly, the present invention relates to a novel compound as shown in the general formula (I) and a pharmaceutically acceptable s

Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.

TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR

The invention relates to compounds of the formula (I) and their use as pharmaceutical ingredients, in particular for the treatment of CNS related diseases.

Steric and electronic control in the addition of hydrazine and phenylhydrazine to α-[(dimethylamino)methylene]-β-oxoarylpropanenitriles

Reaction of hydrazine with α-[(dimethylamino)methylene]-β-oxoarylpropanenitriles 2 gives a mixture of the 4-aroyl-5-aminopyrazoles 3 and the 5-aryl-4-cyanopyrazoles 4. Similarly reaction of 2 with phenylhydrazine gives rise to the 5-amino-4-aroyl-1-phenylpyrazoles 5 and 5-aryl-4-cyano-1-phenylpyrazoles 6. The regioselectivity of addition has been investigated with respect to the electronic nature and steric requirements of the aromatic substitution. The ratio of products was found to be independent of the electronic nature of the substituent. The outcome of the reaction was however very sensitive to steric factors. Substituents in the para- and meta-positions favoured formation of the pyrazole-nitrile products 4 and 6, whereas sterically demanding ortho-substituents favoured the pyrazole-amino ketones 3 and 5.

Synthesis of Substituted 2-Aminoquinoline-1-oxides by Reductive Cyclization of Substituted 3-(2-Nitrophenyl)acrylonitriles

An approach to the class of 2-aminoquinoline-1-oxides is given based on reductive cyclization of appropriate substituted 3-(2-nitrophenyl)acrylonitriles.Thus, 2-nitrobenzylidene compounds 1a-d have been reductively cyclized by H2/PtO2 or H2/Pd-C under nor