benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate

Base Information

• Chemical Name: benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate
• CAS No.: 894801-73-1
• Molecular Formula: C₂₃H₃₅N₃O₄
• Molecular Weight: 417.549
• Mol file: 894801-73-1.mol

Synonyms:benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate

Chemical Property of benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate

There total 1 articles about benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmethyl 1-piperazinecarboxylate (31166-44-6) + (3R)-3-formylpiperidine-1-carboxylic acid tert-butyl ester (194726-46-0) → benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate (894801-73-1)

Guidance literature:

phenylmethyl 1-piperazinecarboxylate; (3R)-3-formylpiperidine-1-carboxylic acid tert-butyl ester; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate (894801-73-1) → benzyl 4-[(3R)-piperidin-3-ylmethyl]piperazine-1-carboxylate (894801-72-0)

Guidance literature:

benzyl 4-{[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methyl}piperazine-1-carboxylate; With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

phenylmethyl 1-piperazinecarboxylate

(3R)-3-formylpiperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

benzyl 4-[(3R)-piperidin-3-ylmethyl]piperazine-1-carboxylate