194726-46-0

Basic information

• Product Name: (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE
• Synonyms: (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE;(R)-tert-butyl 3-formylpiperidine-1-carboxylate;tert-butyl (3R)-3-forMylpiperidine-1-carboxylate;ert-Butyl (3R)-3-formylpiperidine-1-carboxylate;tert-Butyl (R)-3-formylpiperidine-1-carboxylate;(R)-1-Boc-3-piperidinecarboxaldehyde;(R)-1-Boc-3-formyl-piperidine
• CAS NO: 194726-46-0
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.28
• Mol File: 194726-46-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Density: 1.114
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE(194726-46-0)
• EPA Substance Registry System: (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE(194726-46-0)

Safety Data

• Hazardous Substances Data: 194726-46-0(Hazardous Substances Data)

Usage

General Description

(R)-1-(tert-butoxycarbonyl)-3-piperidinecarboxaldehyde is a chemical compound with a molecular formula of C14H23NO4. It is a piperidinecarboxaldehyde derivative that is commonly used in organic synthesis and pharmaceutical research. The tert-butoxycarbonyl (Boc) protecting group is often used to protect the amine group in peptide synthesis. (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE is a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules, making it an important building block in medicinal chemistry. Additionally, it serves as a versatile starting material for the preparation of a wide range of functionalized piperidine derivatives for various biological and pharmaceutical applications.

Upstream product

• 194726-40-4 (3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 445398-78-7 N-benzyl-hepta-4(E),6-dien-1-amine 
• 651321-53-8 Benzyl-[(E)-hepta-4,6-dien-(E)-ylidene]-amine 
• 79280-39-0 (4E)-hepta-4,6-dienal 
• 33741-15-0 methyl (4E)-hepta-4,6-dienoate 
• 934423-10-6 1-(tert-butyl)-3-methyl-(R)-piperidine-1,3-dicarboxylate 
• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 254905-64-1 (3S)-3-(dimethylaminomethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 1381949-95-6 C₂₃H₃₆N₄O₄ 
• 1381949-83-2 C₂₁H₂₉N₅O 
• 1381949-82-1 C₂₁H₂₉N₅O 
• 1381949-81-0 C₂₁H₃₂N₄O₂ 
• 894799-72-5 C₂₀H₂₉ClN₄O 
• 894799-08-7 N-(3,4-dichlorophenyl)-4-[(3R)-piperidin-3-ylmethyl]piperazine-1-carboxamide 

Relevant articles and documents

Palladium-catalyzed ring-closing reaction via C-N bond metathesis for rapid construction of saturated N-heterocycles

The ring-closing reactions based on chemical bond metathesis enable the efficient construction of a wide variety of cyclic systems which receive broad interest from medicinal and organic communities. However, the analogous reaction with C-N bond metathesis as a strategic fundamental step remains an unanswered challenge. Herein, we report the design of a new fundamental metallic C-N bond metathesis reaction that enables the palladium-catalyzed ring-closing reaction of aminodienes with aminals. The reactions proceed efficiently under mild conditions and exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5- to 16-membered N-heterocycles bearing diverse frameworks and functional groups.

Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner-Wadsworth-Emmons-based approach

Integrin inhibitors based on the tripeptide sequence Arg-Gly-Asp (RGD) are potential therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF). Herein, we describe an expeditious three-step synthetic sequence of Horner-Wadsworth-Emmons olefination, diimide reduction, and global deprotection to synthesise cores for these compounds in high yields (63-83% over 3 steps) with no need for chromatography. Key to this transformation is the phosphoramidate protecting group, which is stable to metalation steps.

AZOLE-SUBSTITUTED PYRIDINE COMPOUND

The present invention provides a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3alkanediyl, or the formula -O-CH2CH2-; and ring A represents (a) substituted C4-6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc.