<<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone

Base Information

• Chemical Name: <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone
• CAS No.: 86272-02-8
• Molecular Formula: C₁₉H₁₁ClF₃N₅O
• Molecular Weight: 417.777

Synonyms:<<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone

Chemical Property of <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone

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Technology Process of <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone

There total 3 articles about <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-ylamino)-1H-benzoimidazol-5-yl]-phenyl-methanone (86260-51-7) → <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone (86272-02-8)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 1.5h;

DOI:10.1021/jm00363a017

Reference yield:

(3,4-diaminophenyl)phenylmethanone hydrochloride (57070-71-0) → <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone (86272-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 2-ethoxy-ethanol / 24 h / Heating

2: POCl₃ / 1.5 h / 100 °C

With trichlorophosphate; In 2-ethoxy-ethanol;

DOI:10.1021/jm00363a017

Reference yield:

<4-hydroxy-6-(trifluoromethyl)-2-pyrimidinyl>cyanamide sodium salt (86177-60-8) → <<2-<<4-chloro-6-(trifluormethyl)-2-pyrimidinyl>amino>-1H-benzimidazol-5-yl>phenyl>methanone (86272-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 2-ethoxy-ethanol / 24 h / Heating

2: POCl₃ / 1.5 h / 100 °C

With trichlorophosphate; In 2-ethoxy-ethanol;

DOI:10.1021/jm00363a017

upstream raw materials:

[2-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-ylamino)-1H-benzoimidazol-5-yl]-phenyl-methanone

(3,4-diaminophenyl)phenylmethanone hydrochloride

<4-hydroxy-6-(trifluoromethyl)-2-pyrimidinyl>cyanamide sodium salt

Downstream raw materials:

{2-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone; hydrochloride

(2-{4-[4-Hydroxy-3-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-6-trifluoromethyl-pyrimidin-2-ylamino}-1H-benzoimidazol-5-yl)-phenyl-methanone

{2-[4-(3-Diethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-ylamino]-1H-benzoimidazol-5-yl}-phenyl-methanone

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