(R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

Base Information

Chemical Name:(R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one
CAS No.:686297-87-0
Molecular Formula:C₂₃H₃₈N₄O
Molecular Weight:386.581
Hs Code.:

Synonyms:(R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

Suppliers and Price of (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

There total 1 articles about (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 686297-86-9
{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butylester

: 686297-87-0
(R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

Guidance literature:: {(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butylester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With potassium carbonate; In dichloromethane; water;

Reference yield: 42.0%

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 686297-87-0
(R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

: 686296-57-1
4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid {(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide

Guidance literature:: 1,1'-Carbonyl-di-(1,2,4-triazole); (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one; In tetrahydrofuran; at 0 - 20 ℃; for 1.25h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); for 4h; Heating / reflux;

Reference yield: 29.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 686297-87-0
(R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one

: 79463-77-7
N-cyanodiphenylcarbonimidate

: N-[1-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylamino}-1-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzdiazepin-3-yl)-piperidin-1-yl]-meth-(Z)-yliden]-cyanamide

Guidance literature:: (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-propan-1-one; N-cyanodiphenylcarbonimidate; In dichloromethane; at 20 ℃; for 4h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; In acetonitrile; for 14h; Heating / reflux;