(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

Base Information

Chemical Name:(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate
CAS No.:674776-35-3
Molecular Formula:C₂₆H₃₀N₂O₃
Molecular Weight:418.536
Hs Code.:

Synonyms:(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

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Chemical Property of (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

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Technology Process of (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

There total 8 articles about (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 169221-13-0
(R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one

: 674776-32-0
(+/-)-3-cyano-2-(4-isobutylphenyl)propionyl chloride

: 674776-35-3
(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

: (3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2S)-3-cyano-2-(4-isobutylphenyl)propionate

Guidance literature:: With 3 A molecular sieve; triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tetasy.2003.10.035

Reference yield:

: 61566-33-4
p-isobutylphenylacetic acid methyl ester

: 674776-35-3
(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; hexamethyldisilazane / tetrahydrofuran; hexane / 1.17 h / -78 °C

1.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 96 percent / NaOH / ethanol / 3 h / 20 °C

3.1: 100 percent / PCl₅ / CCl₄ / 40 °C

4.1: 63 percent / Et₃N; 3 Angstroem molecular sieves / CH₂Cl₂ / 0 °C

With sodium hydroxide; n-butyllithium; 3 A molecular sieve; phosphorus pentachloride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; tetrachloromethane; ethanol; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2003.10.035

Reference yield:

: 169221-12-9
(S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone

: 674776-35-3
(3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (2R)-3-cyano-2-(4-isobutylphenyl)propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Et₃N; 3 Angstroem molecular sieves / CH₂Cl₂ / 0 °C

2: 96 percent / LiOH*H₂O; H₂O₂ / tetrahydrofuran / 0 °C

3: 63 percent / Et₃N; 3 Angstroem molecular sieves / CH₂Cl₂ / 0 °C

With lithium hydroxide; 3 A molecular sieve; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2003.10.035