5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Base Information

Chemical Name:5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one
CAS No.:1202804-47-4
Molecular Formula:C₂₁H₁₃Cl₃N₂O₄
Molecular Weight:463.704
Hs Code.:

Synonyms:5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Suppliers and Price of 5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

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Technology Process of 5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

There total 2 articles about 5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33184-33-7
4,5-dichloro-2-(4-chlorobenzoyl)benzoic acid

: 1202804-47-4
5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.07.084

Reference yield:

: 108-90-7
chlorobenzene

: 1202804-47-4
5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / 2 h / 90 °C

2: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

With aluminum (III) chloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1: Friedel Crafts acylation;
DOI:10.1016/j.bmcl.2011.07.084

Reference yield:

: 1202804-47-4
5,6-dichloro-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

: C₂₁H₁₂Cl₄N₂O₃

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.07.084