1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

Base Information

Chemical Name:1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate
CAS No.:1301198-76-4
Molecular Formula:C₃₀H₄₁N₃O₅
Molecular Weight:523.673
Hs Code.:

1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

Synonyms:1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

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Chemical Property of 1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

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Technology Process of 1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

There total 13 articles about 1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1191063-30-5
tert-butyl N-[2-(4-bromophenyl)ethyl]-N-(methyl)carbamate

: 1301198-32-2
1-methylethyl [(2S,4R)-1-acetyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

: 1301198-76-4
1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 100 ℃; for 0.833333h; Inert atmosphere;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1301198-76-4
1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: ((R)-BINAP)ditriflatebis(acetonitrile)palladium(II) / toluene

2: sodium tetrahydroborate; magnesium(II) chloride hexahydrate / ethanol; water / 2 h / -10 - 20 °C

3: pyridine / dichloromethane / Inert atmosphere

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 6 h / 80 °C / Inert atmosphere

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 0.83 h / 100 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; magnesium(II) chloride hexahydrate; potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ((R)-BINAP)ditriflatebis(acetonitrile)palladium(II); In ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1301198-76-4
1-methylethyl [(2S,4R)-1-acetyl-6-(4-{2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]ethyl}phenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

2.2: 2 h / Reflux

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 0.83 h / 100 °C / Inert atmosphere

With sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; mineral oil;