5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

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Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1331783-87-9
Molecular Formula:C₂₃H₁₃Cl₃F₃N₅O₄
Molecular Weight:586.742
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

There total 6 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1331783-86-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-pyrazole-3-carboxamide

: 1331783-87-9
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-pyrazole-3-carboxamide; With sodium periodate; In tetrachloromethane; water; acetonitrile; at 0 ℃; for 0.0833333h;

With ruthenium trichloride; In tetrachloromethane; water; acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1331784-07-6
C₂₃H₁₄BrCl₃F₃N₅O₂

: 1331783-87-9
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver nitrate / water; acetone / 2 h / Reflux

2.1: sodium periodate / tetrachloromethane; water; acetonitrile / 0.08 h / 0 °C

2.2: 0 - 20 °C

With sodium periodate; silver nitrate; In tetrachloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1265634-38-5
C₂₁H₁₅Cl₃N₄O

: 1331783-87-9
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 5 h / Reflux

2.1: 1 h / Reflux

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 14 h / Reflux

4.1: silver nitrate / water; acetone / 2 h / Reflux

5.1: sodium periodate / tetrachloromethane; water; acetonitrile / 0.08 h / 0 °C

5.2: 0 - 20 °C

With sodium periodate; N-Bromosuccinimide; hydroxylamine hydrochloride; potassium carbonate; silver nitrate; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.017