ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate
CAS No.:1331783-88-0
Molecular Formula:C₂₅H₁₇Cl₃F₃N₅O₄
Molecular Weight:614.795
Hs Code.:

ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

There total 8 articles about ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: C₂₃H₁₂Cl₄F₃N₅O₃

: 1331783-88-0
ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:: at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1331784-07-6
C₂₃H₁₄BrCl₃F₃N₅O₂

: 1331783-88-0
ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver nitrate / water; acetone / 2 h / Reflux

2.1: sodium periodate / tetrachloromethane; water; acetonitrile / 0.08 h / 0 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / chloroform / 1 h / Reflux

4.1: 1 h / 20 °C

With sodium periodate; thionyl chloride; silver nitrate; In tetrachloromethane; chloroform; water; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1265634-38-5
C₂₁H₁₅Cl₃N₄O

: 1331783-88-0
ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)cyclopropylcarbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 5 h / Reflux

2.1: 1 h / Reflux

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 14 h / Reflux

4.1: silver nitrate / water; acetone / 2 h / Reflux

5.1: sodium periodate / tetrachloromethane; water; acetonitrile / 0.08 h / 0 °C

5.2: 0 - 20 °C

6.1: thionyl chloride / chloroform / 1 h / Reflux

7.1: 1 h / 20 °C

With sodium periodate; N-Bromosuccinimide; thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; silver nitrate; dibenzoyl peroxide; In tetrachloromethane; ethanol; chloroform; water; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.017