<2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane

Base Information

• Chemical Name: <2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane
• CAS No.: 170708-56-2
• Molecular Formula: C₂₉H₄₆O₄S₃
• Molecular Weight: 554.88
• Mol file: 170708-56-2.mol

Synonyms:<2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane

Chemical Property of <2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane

There total 1 articles about <2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1.3-propanedithiol (109-80-8) + (S)-5-[(2S,3R,6R,8R,9S)-8-((S)-2-Benzenesulfonyl-1-methyl-ethyl)-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3-methyl-pentan-2-one (168334-04-1) → <2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane (170708-56-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; 1.) 0 deg C, 1 h, 2.) room temperature, overnight.;

DOI:10.1016/S0040-4020(97)00230-5

Reference yield:

<2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane (170708-56-2) → (2S,3S,6R)-6-{(2S,3S,6R,8S,9R)-3,9-Dimethyl-8-[(S)-3-(2-methyl-[1,3]dithian-2-yl)-butyl]-1,7-dioxa-spiro[5.5]undec-2-yl}-2-{2-[(4R,5S,6R)-6-isopropyl-5-methoxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl]-[1,3]dithian-2-yl}-heptan-3-ol (189178-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) nBuLi, 2.) BF₃*Et₂O / 1.) hexane, THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h and -50 deg C, 1 h.

2: 71 percent / Na-Hg / methanol

With n-butyllithium; sodium amalgam; boron trifluoride diethyl etherate; In methanol;

DOI:10.1016/S0040-4020(97)00230-5

Reference yield:

<2S,2(3S),3R,6R,8R,8(1S),9S>-3,9-dimethyl-2-<3-(2-methyl-1,3-dithian-2-yl)butyl>-8-<1-methyl-2-(phenylsulfonyl)ethyl>-1,7-dioxaspiro<5,5>undecane (170708-56-2) → (2S,3S,6R)-2-{2-[(2R,3R,4R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-4-(4-methoxy-benzyloxy)-5-methyl-hexyl]-[1,3]dithian-2-yl}-6-{(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(S)-3-(2-methyl-[1,3]dithian-2-yl)-butyl]-1,7-dioxa-spiro[5.5]undec-2-yl}-heptan-3-ol (189177-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) nBuLi, 2.) BF₃*Et₂O / 1.) hexane, THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h and -50 deg C, 1 h.

2: 96 percent / NaHg / methanol

With n-butyllithium; sodium amalgam; boron trifluoride diethyl etherate; In methanol;

DOI:10.1016/S0040-4020(97)00230-5

upstream raw materials:

1.3-propanedithiol

(S)-5-[(2S,3R,6R,8R,9S)-8-((S)-2-Benzenesulfonyl-1-methyl-ethyl)-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3-methyl-pentan-2-one

Downstream raw materials:

C₅₉H₁₀₈O₇S₄Si₂

C₅₉H₉₈O₉S₅Si

C₅₃H₈₂O₉S₅

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