<6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

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Chemical Name:<6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride
CAS No.:135007-81-7
Molecular Formula:C₁₆H₂₄N₂O₅*2ClH
Molecular Weight:397.299
Hs Code.:

Synonyms:<6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

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Chemical Property of <6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

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Technology Process of <6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

There total 6 articles about <6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 134734-09-1
<6-acetoxy-3-N-benzylamino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>carbonitrile

: 135007-81-7
<6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol;
DOI:10.1002/jhet.5570280325

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 135007-81-7
<6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / n-BuLi / hexane; diethyl ether; tetrahydrofuran / 3 h / Ambient temperature

2: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 7 - 15 °C

3: 93 percent / DMAP, DCC / CH₂Cl₂ / Ambient temperature

4: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

5: 89 percent / gl. acetic acid / methanol

6: 96 percent / H₂, ethanol. 2 N HCl / PtO₂ / ethanol

With hydrogenchloride; dmap; n-butyllithium; hydrogen; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; ethyl acetate;
DOI:10.1002/jhet.5570280325

Reference yield:

: 134733-96-3
α-(3,4-dimethoxyphenyl)furfuryl alcohol

: 135007-81-7
<6-acetoxy-3-amino-2-(3,4-dimethoxyphenyl)tetrahydro-2H-pyran-3-yl>methylamine dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 7 - 15 °C

2: 93 percent / DMAP, DCC / CH₂Cl₂ / Ambient temperature

3: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

4: 89 percent / gl. acetic acid / methanol

5: 96 percent / H₂, ethanol. 2 N HCl / PtO₂ / ethanol

With hydrogenchloride; dmap; hydrogen; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; platinum(IV) oxide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1002/jhet.5570280325