1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone

Base Information

• Chemical Name: 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone
• CAS No.: 1201582-48-0
• Molecular Formula: C₁₉H₂₁NO₆
• Molecular Weight: 359.379
• Mol file: 1201582-48-0.mol

Synonyms:1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone

Chemical Property of 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone

There total 6 articles about 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-(2,4-dimethoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone (1201582-47-9) → 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone (1201582-48-0)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; at 110 ℃; for 3h;

Reference yield:

3-acetyl-2,6-dimethoxy-4-methylphenylacetate (1201582-45-7) → 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone (1201582-48-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium nitrate; trifluoroacetic anhydride / chloroform / 2 h / 0 °C

2.1: potassium carbonate / methanol / 3 h / 20 °C

2.2: pH 2

3.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.25 h / 20 °C

3.2: 20 °C

4.1: lithium chloride / N,N-dimethyl-formamide / 3 h / 110 °C

With ammonium nitrate; sodium hydride; potassium carbonate; trifluoroacetic anhydride; lithium chloride; In methanol; chloroform; N,N-dimethyl-formamide; oil;

Reference yield:

1-(3-hydroxy-2,4-dimethoxy-6-methyl-5-nitrophenyl)ethanone (1201582-46-8) → 1-(4-hydroxy-2-methoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone (1201582-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.25 h / 20 °C

1.2: 20 °C

2.1: lithium chloride / N,N-dimethyl-formamide / 3 h / 110 °C

With sodium hydride; lithium chloride; In N,N-dimethyl-formamide; oil;

upstream raw materials:

1-(2,4-dimethoxy-6-methyl-5-nitro-3-(3-phenylpropoxy)phenyl)ethanone

3-acetyl-2,6-dimethoxy-4-methylphenylacetate

1-(3-hydroxy-2,4-dimethoxy-6-methyl-5-nitrophenyl)ethanone

C₁₃H₁₅NO₇

Downstream raw materials:

1-(3-amino-4-hydroxy-6-methoxy-2-methyl-5-(3-phenylpropoxy)phenyl)ethanone

5-acetyl-6-hydroxy-4-methyl-7-(3-phenylpropoxy)benzo[d]oxazole

5-acetyl-6-methoxy-4-methyl-7-(3-phenylpropoxy)benzo[d]oxazole

5-acetyl-6-(2-bromoethoxy)-4-methyl-7-(3-phenylpropoxy)benzo[d]oxazole