2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Base Information

• Chemical Name: 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine
• CAS No.: 115678-27-8
• Molecular Formula: C₃₇H₄₃N₃O₉
• Molecular Weight: 673.763
• Mol file: 115678-27-8.mol

Synonyms:2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Chemical Property of 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

There total 10 articles about 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

N-phthaloylglycine chloride (6780-38-7) + 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (112446-08-9,114030-15-8,115511-18-7,137120-99-1) → 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (115678-27-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jo00253a022

Reference yield:

(Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione (113461-80-6) → 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (115678-27-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 25 °C

2: 1.) lithium tri-tert-butoxyaluminium hydride, 2.) HCOOH / 1.) THF, 1 h, 2.) 60 deg C, 1 h

3: 14 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating

4: H₂ / 20percent Pd/C / ethanol / 24 h / 80 °C / 3040 Torr

5: 89.3 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; lithium aluminium tetrahydride; formic acid; lithium tri(t-butoxy)aluminum hydride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;

DOI:10.1021/jo00253a022

Reference yield:

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine-11-carboxylic acid isopropyl ester (113461-91-9) → 2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine (115678-27-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 14 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating

2: H₂ / 20percent Pd/C / ethanol / 24 h / 80 °C / 3040 Torr

3: 89.3 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;

DOI:10.1021/jo00253a022

upstream raw materials:

N-phthaloylglycine chloride

2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8,11-dimethyl-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one