(R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

Base Information

Chemical Name:(R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate
CAS No.:839710-63-3
Molecular Formula:C₂₄H₂₉NO₅S
Molecular Weight:443.564
Hs Code.:

Synonyms:(R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

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Chemical Property of (R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

Chemical Property:

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Technology Process of (R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

There total 3 articles about (R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131516-05-7
(R)-2-phenyl-2,3-dihydrofuran

: 83670-53-5
ethyl (N-tosylimino)acetate

: 762-72-1
allyl-trimethyl-silane

: (S)-ethyl 2-((2S,3S,5S)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

: 839710-63-3
(R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

Guidance literature:: (R)-2-phenyl-2,3-dihydrofuran; ethyl (N-tosylimino)acetate; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.833333h;

With acetonitrile; In dichloromethane; at -78 ℃; for 0.166667h;

allyl-trimethyl-silane; In dichloromethane; at -78 - 20 ℃; for 3h; Title compound not separated from byproducts;
DOI:10.1021/ol048302j

Reference yield:

: 131516-05-7
(R)-2-phenyl-2,3-dihydrofuran

: 83670-53-5
ethyl (N-tosylimino)acetate

: 762-72-1
allyl-trimethyl-silane

: 839710-63-3
(R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

Guidance literature:: With titanium tetrachloride; acetonitrile; In dichloromethane; at -78 - -20 ℃;
DOI:10.1021/ol061672i

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 839710-63-3
(R)-ethyl 2-((2R,3R,5R)-2-allyl-tetrahydro-5-phenylfuran-3-yl)-2-(tosylamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: TiCl₄; CH₃CN / CH₂Cl₂ / -78 - -20 °C

With titanium tetrachloride; acetonitrile; In dichloromethane;
DOI:10.1021/ol061672i