Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate

Base Information

Chemical Name:Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate
CAS No.:227275-21-0
Molecular Formula:C₁₆H₁₅NO₅
Molecular Weight:301.299
Hs Code.:
DSSTox Substance ID:DTXSID101212243

Synonyms:DTXSID101212243;Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate;227275-21-0

Suppliers and Price of Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:301.09502258
Heavy Atom Count:22
Complexity:400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CC(=CC=C1)OC2=C(C=C(C=C2)C(=O)OC)N

Technology Process of Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate

There total 3 articles about Methyl 3-amino-4-[3-(methoxycarbonyl)phenoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 227275-00-5
dimethyl 3-nitro-3',4-oxydibenzoate

: 227275-21-0
dimethyl 3-amino-3',4-oxydibenzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; at 20 ℃; under 2280 Torr;
DOI:10.1021/jm990342j

Reference yield:

: 19438-10-9
methyl 3-hydroxybenzoate

: 227275-21-0
dimethyl 3-amino-3',4-oxydibenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91.8 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: H₂ / Pd/C / methanol; dioxane / 1 h / 20 °C / 2280 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00023-2

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 227275-21-0
dimethyl 3-amino-3',4-oxydibenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91.8 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: H₂ / Pd/C / methanol; dioxane / 1 h / 20 °C / 2280 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00023-2