1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate

Base Information

• Chemical Name: 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate
• CAS No.: 355024-58-7
• Molecular Formula: C₁₉H₁₆ClN₃O₅
• Molecular Weight: 401.806
• Mol file: 355024-58-7.mol

Synonyms:1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate

Chemical Property of 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate

There total 5 articles about 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2'-chloro-sec-phenethyl alcohol (13524-04-4) + 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylic acid (91135-88-5) → 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate (355024-58-7)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 125 ℃; for 2h; Sealed tube;

Reference yield:

methyl 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylate (1391908-11-4) → 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate (355024-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / 1,4-dioxane / 20 °C

1.2: pH < 6

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 125 °C / Sealed tube

With diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide; In 1,4-dioxane; toluene;

Reference yield:

methyl 2-(4-nitrobenzoyl)-3-oxobutanoate (85963-91-3) → 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-nitrophenyl)isoxazol-4-yl)carbamate (355024-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / acetic acid / 2 h / 115 °C

1.2: 20 °C

2.1: water; lithium hydroxide / 1,4-dioxane / 20 °C

2.2: pH < 6

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 125 °C / Sealed tube

With diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; triethylamine; lithium hydroxide; In 1,4-dioxane; acetic acid; toluene;

upstream raw materials:

2'-chloro-sec-phenethyl alcohol

3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylic acid

methyl 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylate

methyl 2-(4-nitrobenzoyl)-3-oxobutanoate

Downstream raw materials:

1-(2-chlorophenyl)ethyl(5-(4-aminophenyl)-3-methylisoxazol-4-yl)carbamate

1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate