Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate
CAS No.:146537-31-7
Molecular Formula:C₂₀H₁₇BrClNO₂
Molecular Weight:418.717
Hs Code.:

Synonyms:Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

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Chemical Property of Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

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Technology Process of Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

There total 4 articles about Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 706-07-0,5153-70-8
1-chloro-4-(2-nitrovinyl)benzene

: 141-97-9
ethyl acetoacetate

: 106-40-1
4-bromo-aniline

: 146537-31-7
Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: With Fe₃O₄(at)SiO₂ - CPTMS - guanidine - SO₃H(magnetic nanoparticles Fe₃O₄, coated with silica using tetraethoxysilane, modified with (3-chloropropyl)trimethoxysilane (CPTMS) and guanidine, treated with chlorosulfonic acid); In neat (no solvent); at 50 ℃; for 3h;
DOI:10.1134/S1070428019080207

Reference yield: 60.0%

: 141-97-9
ethyl acetoacetate

: 146537-18-0
2-((4-bromophenyl)amino)-1-(4-chlorophenyl)ethan-1-one

: 146537-31-7
Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: With 4-Bromoanilinium bromide; zinc(II) chloride; In benzene; for 20h; Heating;
DOI:10.1016/0223-5234(92)90092-F

Reference yield:

: 106-40-1
4-bromo-aniline

: 146537-31-7
Ethyl 1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / ethanol / 4 h

2: 60 percent / ZnCl₂, p-bromoaniline hydrobromide / benzene / 20 h / Heating

With 4-Bromoanilinium bromide; zinc(II) chloride; In ethanol; benzene;
DOI:10.1016/0223-5234(92)90092-F