8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Base Information

Chemical Name:8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine
CAS No.:214784-93-7
Molecular Formula:C₄₆H₄₉BrN₆O₁₀P₂S₂
Molecular Weight:1051.91
Hs Code.:

8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Synonyms:8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Suppliers and Price of 8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

There total 15 articles about 8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 295805-80-0
8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

: 5625-99-0
N,N'-diphenylphosphorodiamidic chloride

: 214784-93-7
8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Guidance literature:: With 1H-tetrazole; In pyridine; at 20 ℃;
DOI:10.1021/jo0000877

Reference yield: 60.0%

: 67941-87-1
cyclohexylammonium S,S-diphenyl phosphorodithioate

: 214784-96-0
C₃₄H₄₀BrN₆O₉P

: 214784-93-7
8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Guidance literature:: With 1H-tetrazole; triisopropylbenzenesulfonyl chloride; In pyridine; Ambient temperature;
DOI:10.1016/S0040-4039(98)01575-5

Reference yield:

: 295805-79-7
8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

: 214784-93-7
8-bromo-N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(bisphenylthiophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / aq. AcOH / 20 °C

2: 80 percent / tetrazole / pyridine / 20 °C

With 1H-tetrazole; acetic acid; In pyridine; 1: detritylation / 2: Substitution;
DOI:10.1021/jo0000877